Conditions Causing Skin Hyper pigmentation

Sometimes in medical practice patients presents with skin hyperpigmentation or pigmented spots. There are many underlying different causes and they are briefly discussed here:

1. Endocrine Disorders

• Addison’s disease
• Cushing’s syndrome
• Acromegaly
• Nelson’s syndrome
• Pregnancy
• Porphyria

2. Renal Failure

3. Cirrhosis

4. Haemochromatosis

5. Nutritional Causes:

• Vitamin B12 deficiency
• Pellagra

6.. Amyloid

7. Acanthosis nigricans


8. Lymphoma

9. Peutz-Jegher’s syndrome (perioral)

10. Drugs

• Amiodarone
• OCP’s
• Minocycline