Tab Duphaston - Uses, Dosing and Other Information

 

Introduction: Tab Duphaston contains dydrogesterone 10mg which is a synthetic orally active progestogen. 

Indications: 

- Treatment of painful menstrual periods that are not managed by over the counter pain killers.
- Treatment of endometriosis.
- Treatment of missed periods.
- Treatment of irregular cycles.
- Treatment of abnormal uterine bleeding.
- Treatment of pre-menstrual syndrome.
- Treatment of threatened abortion, associated with proven progesterone deficiency.
- Treatment of habitual abortion, with history of repeated miscarriages  associated with proven progesterone deficiency.
- Treatment of infertility due to luteal insufficiency.
- Luteal support as part of an Assisted Reproductive Technology (ART) treatment.
- Hormone replacement therapy.

Duphaston should only be taken upon prescription from your doctor. Different indications need different dosing and duration of treatment. 

Dosing: 

For hormone replacement therapy(Usually Given in post menopausal woman): In combination with continuous oestrogen therapy, take one tablet daily for 14 consecutive days of a 28 day cycle.

 Dysmenorrhoea (painful menstruation): Take one tablet twice daily from day 5 to day 25 of the cycle.

Endometriosis (abnormal growth of uterine tissues outside the uterus): Take one tablet two or three times daily from day 5 to day 25 of the cycle or continuously (as prescribed by the doctor).

Dysfunctional bleeding (to stop bleeding): Take one tablet twice daily for five to seven days.

Dysfunctional bleeding (to prevent bleeding): Take one tablet twice daily from day 11 to day 25 of the cycle.

Amenorrhoea (missed periods with a negative pregnancy test): The doctor should prescribe an oestrogen along with Duphaston. Then take the oestrogen once daily from day 1 to day 25 of the cycle, together with one tablet of dydrogesterone twice daily from day 11 to day 25 of the cycle.

Premenstrual syndrome: Take one tablet twice daily from day 11 to day 25 of the cycle.

Irregular cycles: Take one tablet twice daily from day 11 to day 25 of the cycle.

Threatened abortion(history of bleeding or spotting in early pregnancy): Take four tablets at once, then one tablet every eight hours until symptoms subside.

Habitual abortion(history of repeated miscarriages): Take one tablet twice daily until the twentieth week of pregnancy.

Infertility due to luteal (yellow body) insufficiency (Deficiency of natural production of progesterone hormone): Take one tablet daily from day 14 to 25 of the cycle. Continue the treatment for at least six consecutive cycles. In addition, it is advisable to continue treatment for the first few months of pregnancy as described under "Habitual abortion". If the patient is uncertain about how long to continue the treatment, talk to the doctor.

Luteal support as part of an Assisted Reproductive Technology (ART) treatment: Take one tablet three times daily (30mg daily) starting at the day of oocyte retrieval and continuing for 10 weeks if pregnancy is confirmed.

Side Effects: Duphaston is considered one of the safe drugs with minimal side effects. Some adverse effects observed are 

- Headache

- Nausea/Vomiting

- Abdominal Pain

- Breast tenderness.

Contraindicated to be used when any history of allergy to the medicine and should be avoided when breastfeeding.